Thymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling

Thymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling

Abstract Activated T cells have been shown to be able to recirculate into the thymus from the periphery. The present study was aimed to elucidate the functional consequences of thymic homing of activated T cells upon developing thymocytes and thymic epithelial cells (TEC). In the presence of activat...

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Bibliographic Details
Main Authors: Chen Yin, Xiao-Yan Pei, Hui Shen, Ya-Nan Gao, Xiu-Yuan Sun, Wei Wang, Qing Ge, Yu Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02653-9

Internet

https://doi.org/10.1038/s41598-017-02653-9

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