Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms

Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms

Protection of genome integrity is vital for all living organisms, particularly when DNA double-strand breaks (DSBs) occur. Eukaryotes have developed two main pathways, namely Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR), to repair DSBs. While most of the current research is fo...

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Main Authors: Angelos Papaspyropoulos, Nefeli Lagopati, Ioanna Mourkioti, Andriani Angelopoulou, Spyridon Kyriazis, Michalis Liontos, Vassilis Gorgoulis, Athanassios Kotsinas
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
long non-coding RNAs
double-strand breaks (DSB)
DNA damage response and repair (DDRR)
tumorigenesis
Online Access:https://www.mdpi.com/2073-4409/10/6/1506
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spelling doaj-a9198120a4f64dd58872f65c9a082e642021-07-01T00:13:10ZengMDPI AGCells2073-44092021-06-01101506150610.3390/cells10061506Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair MechanismsAngelos Papaspyropoulos0Nefeli Lagopati1Ioanna Mourkioti2Andriani Angelopoulou3Spyridon Kyriazis4Michalis Liontos5Vassilis Gorgoulis6Athanassios Kotsinas7Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National Kapodistrian University of Athens (NKUA), 75 Mikras Asias Str., Goudi, GR-11527 Athens, GreeceProtection of genome integrity is vital for all living organisms, particularly when DNA double-strand breaks (DSBs) occur. Eukaryotes have developed two main pathways, namely Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR), to repair DSBs. While most of the current research is focused on the role of key protein players in the functional regulation of DSB repair pathways, accumulating evidence has uncovered a novel class of regulating factors termed non-coding RNAs. Non-coding RNAs have been found to hold a pivotal role in the activation of DSB repair mechanisms, thereby safeguarding genomic stability. In particular, long non-coding RNAs (lncRNAs) have begun to emerge as new players with vast therapeutic potential. This review summarizes important advances in the field of lncRNAs, including characterization of recently identified lncRNAs, and their implication in DSB repair pathways in the context of tumorigenesis.https://www.mdpi.com/2073-4409/10/6/1506long non-coding RNAsdouble-strand breaks (DSB)DNA damage response and repair (DDRR)tumorigenesis
collection DOAJ
language English
format Article
sources DOAJ
author Angelos Papaspyropoulos
Nefeli Lagopati
Ioanna Mourkioti
Andriani Angelopoulou
Spyridon Kyriazis
Michalis Liontos
Vassilis Gorgoulis
Athanassios Kotsinas
spellingShingle Angelos Papaspyropoulos
Nefeli Lagopati
Ioanna Mourkioti
Andriani Angelopoulou
Spyridon Kyriazis
Michalis Liontos
Vassilis Gorgoulis
Athanassios Kotsinas
Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms
Cells
long non-coding RNAs
double-strand breaks (DSB)
DNA damage response and repair (DDRR)
tumorigenesis
author_facet Angelos Papaspyropoulos
Nefeli Lagopati
Ioanna Mourkioti
Andriani Angelopoulou
Spyridon Kyriazis
Michalis Liontos
Vassilis Gorgoulis
Athanassios Kotsinas
author_sort Angelos Papaspyropoulos
title Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms
title_short Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms
title_full Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms
title_fullStr Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms
title_full_unstemmed Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms
title_sort regulatory and functional involvement of long non-coding rnas in dna double-strand break repair mechanisms
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2021-06-01
description Protection of genome integrity is vital for all living organisms, particularly when DNA double-strand breaks (DSBs) occur. Eukaryotes have developed two main pathways, namely Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR), to repair DSBs. While most of the current research is focused on the role of key protein players in the functional regulation of DSB repair pathways, accumulating evidence has uncovered a novel class of regulating factors termed non-coding RNAs. Non-coding RNAs have been found to hold a pivotal role in the activation of DSB repair mechanisms, thereby safeguarding genomic stability. In particular, long non-coding RNAs (lncRNAs) have begun to emerge as new players with vast therapeutic potential. This review summarizes important advances in the field of lncRNAs, including characterization of recently identified lncRNAs, and their implication in DSB repair pathways in the context of tumorigenesis.
topic long non-coding RNAs
double-strand breaks (DSB)
DNA damage response and repair (DDRR)
tumorigenesis
url https://www.mdpi.com/2073-4409/10/6/1506
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