Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms

Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms

Protection of genome integrity is vital for all living organisms, particularly when DNA double-strand breaks (DSBs) occur. Eukaryotes have developed two main pathways, namely Non-Homologous End Joining (NHEJ) and Homologous Recombination (HR), to repair DSBs. While most of the current research is fo...

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Bibliographic Details
Main Authors: Angelos Papaspyropoulos, Nefeli Lagopati, Ioanna Mourkioti, Andriani Angelopoulou, Spyridon Kyriazis, Michalis Liontos, Vassilis Gorgoulis, Athanassios Kotsinas
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
long non-coding RNAs
double-strand breaks (DSB)
DNA damage response and repair (DDRR)
tumorigenesis
Online Access:https://www.mdpi.com/2073-4409/10/6/1506

Internet

https://www.mdpi.com/2073-4409/10/6/1506

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