Protein Comparability Assessments and Potential Applicability of High Throughput Biophysical Methods and Data Visualization Tools to Compare Physical Stability Profiles

Protein Comparability Assessments and Potential Applicability of High Throughput Biophysical Methods and Data Visualization Tools to Compare Physical Stability Profiles

In this review, some of the challenges and opportunities encountered during protein comparability assessments are summarized with an emphasis on developing new analytical approaches to better monitor higher-order protein structures. Several case studies are presented using high throughput biophysic...

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Bibliographic Details
Main Authors: Mohammad A. Alsenaidy, Nishant K. eJain, Jae H. Kim, C. Russel Middaugh, David B. Volkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Pharmacology
Subjects:
data visualization
stability
review
monoclonal antibodies
formulation
high throughput
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00039/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00039/full

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