Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects

Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects

Macrophages exhibit phenotypic heterogeneity under both physiological and pathological conditions. Applications targeting M2-like tumor-associated macrophages (TAMs) improve outcome in solid tumors. Considerable differences are detected between leukemia-associated macrophages (LAMs) and TAMs. Howeve...

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Bibliographic Details
Main Authors: Xiao Yang, Wenli Feng, Rong Wang, Feifei Yang, Lina Wang, Shayan Chen, Yongxin Ru, Tao Cheng, Guoguang Zheng
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
irf7
leukemia-associated macrophages
phenotypic heterogeneity
phenotype conversion
sapk/jnk pathway
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1412910

Internet

http://dx.doi.org/10.1080/2162402X.2017.1412910

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