Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes

Li et al. design and synthesize fluorescently labeled molecular tweezers to explore their internalization, intracellular localization, and mechanism of endocytosis in brain cells including neurons and astrocytes. The authors find that MTs are internalized in neurons and astrocytes, at least partiall...

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Bibliographic Details
Main Authors: Zizheng Li, Ibrar Siddique, Inesa Hadrović, Abbna Kirupakaran, Jiwen Li, Ye Zhang, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02603-2