A Synaptic Mechanism Underlying the Behavioral Abnormalities Induced by Manganese Intoxication

A Synaptic Mechanism Underlying the Behavioral Abnormalities Induced by Manganese Intoxication

In the present study we have characterized a rat model of manganese (Mn) intoxication leading to behavioral disinhibition in the absence of major motor alterations. These behavioral changes were associated with significantly increased brain Mn levels but were uncoupled to anatomical lesions of the s...

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Bibliographic Details
Main Authors: Paolo Calabresi, Martine Ammassari-Teule, Paolo Gubellini, Giuseppe Sancesario, Maria Morello, Diego Centonze, Girolama A. Marfia, Emilia Saulle, Enrica Passino, Barbara Picconi, Giorgio Bernardi
Format: Article
Language:English
Published: Elsevier 2001-06-01
Series:Neurobiology of Disease
Subjects:
basal ganglia
dopamine receptors
learning
movement disorders
parkinsonism
striatum
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996100903796

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http://www.sciencedirect.com/science/article/pii/S0969996100903796

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