Local function conservation in sequence and structure space.

We assess the variability of protein function in protein sequence and structure space. Various regions in this space exhibit considerable difference in the local conservation of molecular function. We analyze and capture local function conservation by means of logistic curves. Based on this analysis...

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Bibliographic Details
Main Authors: Nils Weinhold, Oliver Sander, Francisco S Domingues, Thomas Lengauer, Ingolf Sommer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2427199?pdf=render