The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury

The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury

Early and adequate restoration of endothelial and tubular renal function is a substantial step during regeneration after ischemia reperfusion (IR) injury, occurring, e.g., in kidney transplantation, renal surgery, and sepsis. While tubular epithelial cell injury has long been of central importance,...

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Bibliographic Details
Main Authors: Dania Fischer, Christopher Seifen, Patrick Baer, Michaela Jung, Christina Mertens, Bertram Scheller, Kai Zacharowski, Rainer Hofmann, Thorsten J. Maier, Anja Urbschat
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
FX06
renal ischemia reperfusion injury
endothelial activation
tubular regeneration
angiogenesis
primary mouse proximal tubular cells
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00369/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00369/full

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