Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects

Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects

The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates many important cellular functions. The functional impact of deregulating the PIK3CA gene, encoding the p110α catalytic subunit of PI3K, is validated by frequent gain of function mutations in a range of human cancers. We generated a...

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Bibliographic Details
Main Authors: Sheen Mee Rie, Warner Sandra L., Fields Jennifer L., Conejo-Garcia Jose R., Fiering Steven
Format: Article
Language:English
Published: De Gruyter 2015-10-01
Series:Open Life Sciences
Subjects:
PIK3CA
p110α
Cre recombinase
myristoylated
lethality
embryonic development
morphological malformation
hemorrhage
vasculogenesis
angiogenesis
Online Access:http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0048/biol-2015-0048.xml?format=INT

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http://www.degruyter.com/view/j/biol.2015.10.issue-1/biol-2015-0048/biol-2015-0048.xml?format=INT

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