Creatine transporter (SLC6A8) knock out mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle

Creatine transporter (SLC6A8) knock out mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle

The present study aimed to investigate whether skeletal muscle from whole body creatine transporter (CrT; SLC6A8) knockout mice (CrT-/y) actually contained creatine (Cr) and if so, whether this Cr could result from an up regulation of muscle Cr biosynthesis. Gastrocnemius muscle from CrT-/y and wild...

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Bibliographic Details
Main Authors: Aaron Paul Russell, Lobna eGhobrial, Craig Robert Wright, Severine eLamon, Erin eBrown, Michihiro eKon, Matthew eSkelton, Rodney eSnow
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Physiology
Subjects:
Creatine
Energy Metabolism
skeletal muscle
Creatine transporter
creatine synthesis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00314/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00314/full

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