Synthesis and Biological Evaluation of Lipophilic 1,4-Naphthoquinone Derivatives against Human Cancer Cell Lines

Synthesis and Biological Evaluation of Lipophilic 1,4-Naphthoquinone Derivatives against Human Cancer Cell Lines

To examine the effect of hydrophobicity on the anticancer activity of 1,4-naphthoquinone derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl- or 2/3-N-morpholinoalkyl group were synthesized and evaluated for their anticancer activity against five human cancer cell lines in vitro. The...

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Bibliographic Details
Main Authors: Shao-Hung Wang, Chih-Yu Lo, Zhong-Heng Gwo, Hong-Jhih Lin, Lih-Geeng Chen, Cheng-Deng Kuo, Jin-Yi Wu
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
1,4-naphthoquinone
terpenoids
anticancer activity
human colon cancer cells HT-29
cell cycle distribution
apoptosis
Online Access:http://www.mdpi.com/1420-3049/20/7/11994

Internet

http://www.mdpi.com/1420-3049/20/7/11994

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