CRISPR-mediated base editing in mice using cytosine deaminase base editor 4

CRISPR-mediated base editing in mice using cytosine deaminase base editor 4

Background: Many human genetic diseases arise from point mutations. These genetic diseases can theoretically be corrected through gene therapy. However, gene therapy in clinical application is still far from mature. Nearly half of the pathogenic single-nucleotide polymorphisms (SNPs) are caused by G...

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Bibliographic Details
Main Authors: Salah Adlat, Farooq Hayel, Ping Yang, Yang Chen, Zin Mar Oo, May Zun Zaw Myint, Rajiv Kumar Sah, Noor Bahadar, Mahmoud Al-Azab, Fatoumata Binta Bah, Yaowu Zheng, Xuechao Feng
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Electronic Journal of Biotechnology
Subjects:
Base editor 4
CRISPR-Cas9
Cytosine base editing
Cytosine Deaminase
Mouse model
Single-base substitution
Online Access:http://www.sciencedirect.com/science/article/pii/S0717345821000257

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http://www.sciencedirect.com/science/article/pii/S0717345821000257

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