High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct

High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct

Abstract Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, including fibronectin, collagen, and transform...

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Bibliographic Details
Main Authors: Venkateswara R. Gogulamudi, Danielle Y. Arita, Camille R. T. Bourgeois, Justine Jorgensen, Jing He, William C. Wimley, Ryosuke Satou, Alexis A. Gonzalez, Minolfa C. Prieto
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93296-4

Internet

https://doi.org/10.1038/s41598-021-93296-4

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