In Vitro and in Vivo Effects of Alkyl Nitrites on Methionine Synthase from Mouse Kidney and Liver

The effect of butyl and isoamyl nitrites on methionine synthase from mouse kidney and liver was investigated. A strong specific inhibition of the enzyme (50% at 7.3 x 10 4 M nitrites for kidney methionine synthase) was found. This inhibition was caused mainly by the destruction of vitamin B12 as sho...

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Bibliographic Details
Main Authors: Manteuffel-Cymborowska Malgorzata, Chmurzyńska Wanda, Kamińska Bożena, Sikora Ewa, Grzelakowska-Sztabert Barbara
Format: Article
Language:English
Published: De Gruyter 1989-08-01
Series:Pteridines
Online Access:https://doi.org/10.1515/pteridines.1989.1.3.171