Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

Fhit protein is lost or reduced in a large fraction of human tumors, and its restoration triggers apoptosis and suppresses tumor formation or progression in preclinical models. Here, we describe the identification of candidate Fhit-interacting proteins with cytosolic and plasma membrane localization...

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Bibliographic Details
Main Authors: Eugenio Gaudio, Francesco Paduano, Riccardo Spizzo, Apollinaire Ngankeu, Nicola Zanesi, Marco Gaspari, Francesco Ortuso, Francesca Lovat, Jonathan Rock, Grace A Hill, Mohamed Kaou, Giovanni Cuda, Rami I Aqeilan, Stefano Alcaro, Carlo M Croce, Francesco Trapasso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3819369?pdf=render

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http://europepmc.org/articles/PMC3819369?pdf=render

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