A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA2)

A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA2)

Spongy degeneration with cerebellar ataxia (SDCA) is a genetically heterogeneous neurodegenerative disorder with autosomal recessive inheritance in Malinois dogs, one of the four varieties of the Belgian Shepherd breed. Using a combined linkage and homozygosity mapping approach we identified an ∼10....

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Bibliographic Details
Main Authors: Nico Mauri, Miriam Kleiter, Elisabeth Dietschi, Michael Leschnik, Sandra Högler, Michaela Wiedmer, Joëlle Dietrich, Diana Henke, Frank Steffen, Simone Schuller, Corinne Gurtner, Nadine Stokar-Regenscheit, Donal O’Toole, Thomas Bilzer, Christiane Herden, Anna Oevermann, Vidhya Jagannathan, Tosso Leeb
Format: Article
Language:English
Published: Oxford University Press 2017-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Canis familiaris
canine
Malinois
Na+/K+-ATPase
β2 subunit
adhesion molecule on glia
AMOG
astrocytes
brain
central nervous system
epilepsy
KCNJ10
cerebellar dysfunction
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.043018

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.043018

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