Chemotherapeutic Drugs Induce PPAR-γ Expression and Show Sequence-Specific Synergy with PPAR-γ Ligands in Inhibition of Non–Small Cell Lung Cancer

Chemotherapeutic Drugs Induce PPAR-γ Expression and Show Sequence-Specific Synergy with PPAR-γ Ligands in Inhibition of Non–Small Cell Lung Cancer

Preclinical studies have shown that peroxisome proliferator–activated receptor γ (PPAR-γ) ligands can exert antitumor effects against non–small cell lung cancer (NSCLC) and a variety of other cancers. In this study, we investigate the potential use of a PPAR-γ ligand, troglitazone (Tro), in combina...

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Bibliographic Details
Main Authors: Raju C. Reddy, Anjaiah Srirangam, Kaunteya Reddy, Jun Chen, Srinivasareddy Gangireddy, Gregory P. Kalemkerian, Theodore J. Standiford, Venkateshwar G. Keshamouni
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608801480

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http://www.sciencedirect.com/science/article/pii/S1476558608801480

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