GluN2B-containg NMDA receptors on adult-born granule cells contribute to the antidepressant action of fluoxetine

Ablation of adult neurogenesis in mice has revealed that young adult-born granule cells (abGCs) are required for some of the behavioral responses to antidepressants (ADs), yet the mechanism by which abGCs contribute to AD action remains unknown. During their maturation process, immature neurons exhi...

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Bibliographic Details
Main Authors: Lindsay eTannenholz, Rene eHen, Mazen A Kheirbek
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00242/full