Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation

Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation

Abstract Background Altered mitochondrial function and large-scale changes to DNA methylation patterns in the nuclear genome are both hallmarks of colorectal cancer (CRC). Mitochondria have multiple copies of a 16 kb circular genome that contains genes that are vital for their function. While DNA me...

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Bibliographic Details
Main Authors: M. J. Morris, L. B. Hesson, R. C. Poulos, R. L. Ward, J. W. H. Wong, N. A. Youngson
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Biomarker Research
Subjects:
Colorectal cancer
Adenoma
DNA methylation
mtDNA
Mitochondria
Online Access:http://link.springer.com/article/10.1186/s40364-018-0151-x

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http://link.springer.com/article/10.1186/s40364-018-0151-x

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