Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers

Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers

Cross-linking mass spectrometry can provide insights into protein structures and interactions but its scope depends on the reactivity of the cross-linker. Here, the authors develop Arg-Arg and Lys-Arg cross-linkers, which provide structural information elusive to the widely used Lys-Lys cross-linker...

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Bibliographic Details
Main Authors: Alexander X. Jones, Yong Cao, Yu-Liang Tang, Jian-Hua Wang, Yue-He Ding, Hui Tan, Zhen-Lin Chen, Run-Qian Fang, Jili Yin, Rong-Chang Chen, Xing Zhu, Yang She, Niu Huang, Feng Shao, Keqiong Ye, Rui-Xiang Sun, Si-Min He, Xiaoguang Lei, Meng-Qiu Dong
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11917-z

Internet

https://doi.org/10.1038/s41467-019-11917-z

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