NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

Summary: Cancer stem cells (CSCs) are associated with the refractory nature of cancer, and elucidating the targetable pathways for CSCs is crucial for devising innovative antitumor therapies. We find that the proliferation of CSC-enriched colon spheroids from clinical specimen is dependent on mTORC1...

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Bibliographic Details
Main Authors: Hirokazu Ohata, Daisuke Shiokawa, Yuuki Obata, Ai Sato, Hiroaki Sakai, Mayu Fukami, Wakako Hara, Hirokazu Taniguchi, Masaya Ono, Hitoshi Nakagama, Koji Okamoto
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719308654

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http://www.sciencedirect.com/science/article/pii/S2211124719308654

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