Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

Summary: Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to abnormal activity of ion channels or neurotransmitter receptors. We studied three Gβ1 mutations (K78R, I80N and I80T) using computational a...

Full description

Bibliographic Details
Main Authors: Haritha P. Reddy, Daniel Yakubovich, Tal Keren-Raifman, Galit Tabak, Vladimir A. Tsemakhovich, Maria H. Pedersen, Boris Shalomov, Sophie Colombo, David B. Goldstein, Jonathan A. Javitch, Amal K. Bera, Nathan Dascal
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:iScience
Subjects:
Biological sciences
Molecular neuroscience
Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422100986X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422100986X

Similar Items