Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes

Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes

Methicillin-resistant Staphylococcus aureus (MRSA) poses a substantial threat to human health worldwide and evolves rapidly by acquiring mobile genetic elements, such as plasmids. Here we investigate how the copB-mco copper hypertolerance operon carried on a mobile genetic element contributes to the...

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Bibliographic Details
Main Authors: Marta Zapotoczna, Gustavo P. Riboldi, Ahmed M. Moustafa, Elizabeth Dickson, Apurva Narechania, Julie A. Morrissey, Paul J. Planet, Matthew T. G. Holden, Kevin J. Waldron, Joan A. Geoghegan
Format: Article
Language:English
Published: American Society for Microbiology 2018-10-01
Series:mBio
Subjects:
MRSA
P-type ATPase
Staphylococcus aureus
copper tolerance
macrophages
metals
mobile genetic elements
multicopper oxidase
Online Access:https://doi.org/10.1128/mBio.00550-18

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