Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses.

Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses.

Abacavir hypersensitivity is a severe hypersensitivity reaction which occurs exclusively in carriers of the HLA-B*57∶01 allele. In vitro culture of PBMC with abacavir results in the outgrowth of abacavir-reacting CD8+ T cells, which release IFNγ and are cytotoxic. How this immune response is induced...

Full description

Bibliographic Details
Main Authors: Jacqueline Adam, Natascha Wuillemin, Stephan Watkins, Heidi Jamin, Klara K Eriksson, Peter Villiger, Stefano Fontana, Werner J Pichler, Daniel Yerly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3994040?pdf=render

Internet

http://europepmc.org/articles/PMC3994040?pdf=render

Similar Items