Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition

Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition

Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder associated with deficits in cognition and synaptic plasticity. While accumulation of amyloid β (Aβ) and hyper-phosphorylation of tau are parts of the etiology, AD can be caused by a large number of different genetic mutations and othe...

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Bibliographic Details
Main Authors: Kyoung-Doo Hwang, Myeong Seong Bak, Sang Jeong Kim, Sangmyung Rhee, Yong-Seok Lee
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Molecular Brain
Subjects:
Alzheimer’s disease (AD)
Amyloid β (Aβ)
PKR inhibitor (PKRi)
Contextual fear conditioning
Object recognition memory
Long-term potentiation (LTP)
Online Access:http://link.springer.com/article/10.1186/s13041-017-0338-3

Internet

http://link.springer.com/article/10.1186/s13041-017-0338-3

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