Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron accumulates over adult lifetime in Caenorhabditis elegans. Here, we show that glutathione depletion is coupled to ferrous iro...

Full description

Bibliographic Details
Main Authors: Nicole L Jenkins, Simon A James, Agus Salim, Fransisca Sumardy, Terence P Speed, Marcus Conrad, Des R Richardson, Ashley I Bush, Gawain McColl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
iron
ferroptosis
frailty
lifespan
glutathione
fitness
Online Access:https://elifesciences.org/articles/56580

Internet

https://elifesciences.org/articles/56580

Similar Items