Anti-nociceptive and Anti-inflammatory Activities of Asparacosin A Involve Selective Cyclooxygenase 2 and Inflammatory Cytokines Inhibition: An in-vitro, in-vivo, and in-silico Approach

Anti-nociceptive and Anti-inflammatory Activities of Asparacosin A Involve Selective Cyclooxygenase 2 and Inflammatory Cytokines Inhibition: An in-vitro, in-vivo, and in-silico Approach

Triterpenes possess anti-inflammatory and anti-nociceptive effects. In this study anti-inflammatory activities of Asparacosin A were evaluated' using in-vitro cyclooxygenases 1 and 2 (COX-1/2) inhibition assays. Moreover, anti-nociceptive activities were assessed in-vivo by carrageenan-induced...

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Bibliographic Details
Main Authors: Nasiara Karim, Inamullah Khan, Waheed Khan, Imran Khan, Ajmal Khan, Sobia Ahsan Halim, Hizbullah Khan, Javid Hussain, Ahmed Al-Harrasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
Asparacosin A
acetic acid-induced writhing test
formalin test
carrageenan-induced paw edema
xylene-induced ear edema
docking studies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00581/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00581/full

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