Inhibition of Collagen Related Peptide Induced Platelet Activation and Apoptosis by Ceritinib

Inhibition of Collagen Related Peptide Induced Platelet Activation and Apoptosis by Ceritinib

Background/Aims: The anaplastic lymphoma (tyrosine) kinase (ALK) inhibitor ceritinib triggers apoptosis of tumor cells and eryptosis of erythrocytes. Blood platelets may similarly enter a state resembling apoptosis, which could be triggered by activation with collagen related peptide (CRP). CRP-indu...

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Bibliographic Details
Main Authors: Hang Cao, Anja T. Umbach, Rosi Bissinger, Meinrad Gawaz, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
CRP
Orai1
Cytosolic Ca2+ concentration
Oxidative stress
Platelet activation
Degranulation
Integrin
Caspase
Phosphatidylserine translocation
Cell volume
Online Access:https://www.karger.com/Article/FullText/487778

Internet

https://www.karger.com/Article/FullText/487778

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