Dropout imputation and batch effect correction for single-cell RNA sequencing data

Abstract. Single-cell RNA sequencing (scRNA-seq) allows researchers to examine the transcriptome at the single-cell level and has been increasingly employed as technologies continue to advance. Due to technical and biological reasons unique to scRNA-seq data, denoising and batch effect correction ar...

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Bibliographic Details
Main Authors: Gang Li, Yuchen Yang, Eric Van Buren, Yun Li
Format: Article
Language:English
Published: Wolters Kluwer Health 2019-12-01
Series:Journal of Bio-X Research
Online Access:http://journals.lww.com/10.1097/JBR.0000000000000053