Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s Disease

Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and a concomitant loss of synapses and cognitive abilities. Recently, we have proposed that an alteration of neuronal membrane lipid microdomains increases neuronal resistance toward amyloid-β stress in cultured neurons and p...

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Bibliographic Details
Main Authors: Silke Herzer, Cassidy Hagan, Johanna von Gerichten, Vanessa Dieterle, Bogdan Munteanu, Roger Sandhoff, Carsten Hopf, Viola Nordström
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Alzheimer’s disease
gangliosides
spatial memory
spine density
glial cells
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00206/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00206/full

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