Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells

Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells

New treatment modalities are urgently needed to better manage advanced breast cancer. Combination therapies are usually more effective than monotherapy. In this context, the use of cyclic and acyclic O,N-acetals derivative compounds in combination with the suicide gef gene shown a potent anti-tumor...

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Bibliographic Details
Main Authors: Alberto Ramírez, Ana Conejo-García, Carmen Griñán-Lisón, Luisa C. López-Cara, Gema Jiménez, Joaquín M. Campos, Juan A. Marchal, Houria Boulaiz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
gef gene
1
4-benzoxazepin-2
6-dichloropurine
breast cancer
combined therapy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00798/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00798/full

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