Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases
Lysophosphatidic acid (LPA), generated in the microenvironment of cancer cells, can drive the proliferation, invasion, and migration of cancer cells by activating G protein-coupled LPA receptors. Moreover, in cancer cells that have metastasized to bone, LPA signaling can promote osteolysis by induci...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-08-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2227-9032/4/3/60 |