Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation

Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation

Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a major NADH shuttle - in inflammation has remained unclear. In t...

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Bibliographic Details
Main Authors: Cuiyan Zhou, Wangsong Shang, Shan-Kai Yin, Haibo Shi, Weihai Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
malate-aspartate shuttle
neuroinflammation
aminooxyacetic acid
pyruvate
stat3
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.655687/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.655687/full

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