The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses.

The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses.

The equine herpesvirus type 1 (EHV-1) ORF1 and ORF71 genes have immune modulatory effects in vitro. Experimental infection of horses using virus mutants with multiple deletions including ORF1 and ORF71 showed promise as vaccine candidates against EHV-1. Here, the combined effects of ORF1 and ORF71 d...

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Bibliographic Details
Main Authors: Christine L Wimer, Christiane L Schnabel, Gillian Perkins, Susanna Babasyan, Heather Freer, Alison E Stout, Alicia Rollins, Nikolaus Osterrieder, Laura B Goodman, Amy Glaser, Bettina Wagner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6237298?pdf=render

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http://europepmc.org/articles/PMC6237298?pdf=render

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