Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways.
The chemical-genetic profile can be defined as quantitative values of deletion strains' growth defects under exposure to chemicals. In yeast, the compendium of chemical-genetic profiles of genomewide deletion strains under many different chemicals has been used for identifying direct target pro...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-01-01
|
| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC2515108?pdf=render |