Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

Background: Delirium in elderly patients is common and dangerous. Major risk factors include aging and exogenous insults, such as infection or surgery. In animal models, aging enhances pro-inflammatory cytokine release from microglia in response to exogenous insults. The epigenetic mechanism DNA met...

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Bibliographic Details
Main Authors: Gen Shinozaki, Patricia R. Braun, Benjamin W. Q. Hing, Andrew Ratanatharathorn, Mason J. Klisares, Gabrielle N. Duncan, Sydney S. Jellison, Jonathan T. Heinzman, Yasunori Nagahama, Liesl Close, Sayeh Sabbagh, Brian J. Dlouhy, Matthew A. Howard, Hiroto Kawasaki, Hyunkeun R. Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
delirium
epigenetics
DNA methylation
cytokine
tNF-alpha
aging
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00311/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2018.00311/full

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