Targeting Tumor-Associated Macrophages as a Potential Strategy to Enhance the Response to Immune Checkpoint Inhibitors

Inhibition of immune checkpoint pathways in CD8+ T cell is a promising therapeutic strategy for the treatment of solid tumors that has shown significant anti-tumor effects and is now approved by the FDA to treat patients with melanoma and lung cancer. However the response to this therapy is limited...

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Bibliographic Details
Main Authors: Luca Cassetta, Takanori Kitamura
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TAM
Online Access:http://journal.frontiersin.org/article/10.3389/fcell.2018.00038/full