Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression

Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression

Summary: Janus kinases (JAKs) and their downstream STAT proteins play key roles in cytokine signaling, tissue homeostasis, and cancer development. Using a breast cancer model that conditionally lacks Janus kinase 1, we show here that JAK1 is essential for IL-6-class inflammatory cytokine signaling a...

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Bibliographic Details
Main Authors: Barbara L. Wehde, Patrick D. Rädler, Hridaya Shrestha, Stevi J. Johnson, Aleata A. Triplett, Kay-Uwe Wagner
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471831667X

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http://www.sciencedirect.com/science/article/pii/S221112471831667X

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