Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation

Diagnosis of breast ductal carcinoma in situ (DCIS) presents a challenge since we cannot yet distinguish those cases that would remain indolent and not require aggressive treatment from cases that may progress to invasive ductal cancer (IDC). The purpose of this study is to determine the role of Rap...

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Bibliographic Details
Main Authors: Seema Shah, Ethan J. Brock, Ryan M. Jackson, Kyungmin Ji, Julie L. Boerner, Bonnie F. Sloane, Raymond R. Mattingly
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558617305742