Ligand Activation of the Androgen Receptor Downregulates E-Cadherin-Mediated Cell Adhesion and Promotes Apoptosis of Prostatic Cancer Cells

Ligand Activation of the Androgen Receptor Downregulates E-Cadherin-Mediated Cell Adhesion and Promotes Apoptosis of Prostatic Cancer Cells

Androgen independence is the major cause of endocrine therapy failure in advanced prostate cancer (PC). To examine the effects of human androgen receptor (AR) expression on growth of human PC cells, transfection of full-length AR cDNA in an androgen-insensitive human prostatic adenocarcinoma cell l...

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Bibliographic Details
Main Authors: Joanna Nightingale, Khurram S. Chaudhary, Paul D. Abel, Andrew P. Stubbs, Hanna M. Romanska, Stephen E. Mitchell, Gordon W.H. Stamp, El-Nasir Lalani
Format: Article
Language:English
Published: Elsevier 2003-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
androgen receptor
ligand
prostate cancer
E-cadherin
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800283

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http://www.sciencedirect.com/science/article/pii/S1476558603800283

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