OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

The recent introduction of novel β-lactam/β-lactamase inhibitor combinations like ceftazidime-avibactam has increased our ability to treat infections caused by multidrug-resistant Gram-negative bacteria, including carbapenemase-producing Enterobacterales. However, the increasing number of cases of r...

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Bibliographic Details
Main Authors: Christopher Fröhlich, Vidar Sørum, Ane Molden Thomassen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Ørjan Samuelsen
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mSphere
Subjects:
Escherichia coli
Klebsiella pneumoniae
OXA-48
carbapenem
carbapenemase
ceftazidime
ceftazidime-avibactam
collateral sensitivity
evolution
resistance development
Online Access:https://doi.org/10.1128/mSphere.00024-19

Internet

https://doi.org/10.1128/mSphere.00024-19

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