Echinacoside Suppresses Amyloidogenesis and Modulates F-actin Remodeling by Targeting the ER Stress Sensor PERK in a Mouse Model of Alzheimer’s Disease

Echinacoside Suppresses Amyloidogenesis and Modulates F-actin Remodeling by Targeting the ER Stress Sensor PERK in a Mouse Model of Alzheimer’s Disease

Endoplasmic reticulum stress (ERS) plays a vital and pathogenic role in the onset and progression of Alzheimer’s disease (AD). Phosphorylation of PKR-like endoplasmic reticulum kinase (PERK) induced by ERS depresses the interaction between actin-binding protein filamin-A (FLNA) and PERK, which promo...

Full description

Bibliographic Details
Main Authors: Yuan Dai, Guanghui Han, Shijun Xu, Yongna Yuan, Chunyan Zhao, Tao Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Alzheimer’s disease
echinacoside
endoplasmic reticulum stress
filamin-A
amyloid β
f-actin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.593659/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.593659/full

Similar Items