Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta...
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Bibliographic Details
| Main Authors: |
Christos Karampelias,
Habib Rezanejad,
Mandy Rosko,
Likun Duan,
Jing Lu,
Laura Pazzagli,
Philippe Bertolino,
Carolyn E. Cesta,
Xiaojing Liu,
Gregory S. Korbutt,
Olov Andersson |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23673-0
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