Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta...

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Bibliographic Details
Main Authors: Christos Karampelias, Habib Rezanejad, Mandy Rosko, Likun Duan, Jing Lu, Laura Pazzagli, Philippe Bertolino, Carolyn E. Cesta, Xiaojing Liu, Gregory S. Korbutt, Olov Andersson
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23673-0

Internet

https://doi.org/10.1038/s41467-021-23673-0

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