Real-time observation of signal recognition particle binding to actively translating ribosomes

Real-time observation of signal recognition particle binding to actively translating ribosomes

The signal recognition particle (SRP) directs translating ribosome-nascent chain complexes (RNCs) that display a signal sequence to protein translocation channels in target membranes. All previous work on the initial step of the targeting reaction, when SRP binds to RNCs, used stalled and non-transl...

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Bibliographic Details
Main Authors: Thomas R Noriega, Jin Chen, Peter Walter, Joseph D Puglisi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
signal recognition particle
ribosome translation
protein targeting
single molecule fluorescence
Online Access:https://elifesciences.org/articles/04418

Internet

https://elifesciences.org/articles/04418

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