A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

TNF can be inhibited by small molecules that stabilize the TNF trimer in an asymmetric conformation. Here, the authors develop a monoclonal antibody that selectively binds this inactive form of TNF, enabling both target engagement assessment and structural characterization of TNF binding to TNF rece...

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Bibliographic Details
Main Authors: Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O’Connell, Alastair D. G. Lawson
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20825-6

Internet

https://doi.org/10.1038/s41467-020-20825-6

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