An Epidemiological Study of Thiopurinemethyltransferase Variants in a Croatian Inflammatory Bowel Disease Patient Cohort

An Epidemiological Study of Thiopurinemethyltransferase Variants in a Croatian Inflammatory Bowel Disease Patient Cohort

Thiopurine S-methyltransferase (TPMT) is an enzyme that converts thiopurine drugs into inactive metabolites. Over 20 variant TPMT-encoding alleles, which cause reduced enzymatic activity, have been discovered so far. Our aim was to investigate the frequencies of variant alleles, i.e. genotypes in in...

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Bibliographic Details
Main Authors: Vladimir Borzan, Marko Brinar, Boris Vucelić, Silvija Čuković-Čavka, Agata Ladić, Nada Božina
Format: Article
Language:English
Published: Sestre Milosrdnice University hospital, Institute of Clinical Medical Research 2016-01-01
Series:Acta Clinica Croatica
Subjects:
Crohn’s disease – genetics
Colitis, ulcerative – genetics
Thiopurine-S-methyltransferase deficiency
Polymorphism, genetic
Online Access:http://hrcak.srce.hr/file/237733

Internet

http://hrcak.srce.hr/file/237733

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