Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors

Uncoupling DISC1 × D2R Protein-Protein Interactions Facilitates Latent Inhibition in Disc1-L100P Animal Model of Schizophrenia and Enhances Synaptic Plasticity via D2 Receptors

Both Disrupted-In-Schizophrenia-1 (DISC1) and dopamine receptors D2R have significant contributions to the pathogenesis of schizophrenia. Our previous study demonstrated that DISC1 binds to D2R and such protein-protein interaction is enhanced in patients with schizophrenia and Disc1-L100P mouse mode...

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Bibliographic Details
Main Authors: Tatiana V. Lipina, Nikolay A. Beregovoy, Alina A. Tkachenko, Ekaterina S. Petrova, Marina V. Starostina, Qiang Zhou, Shupeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
DISC1
D2R
Disc1-L100P mouse model of schizophrenia
latent inhibition
synaptic plasticity
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00031/full

Internet

https://www.frontiersin.org/article/10.3389/fnsyn.2018.00031/full

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