A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling
It is well established that the tumour microenvironment contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular and immune. Signalling molecules secreted by the tumour corrupts these cells to create ‘activated’ stroma. Equally, the extracellular matrix contributes...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-05-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00033/full |
| id |
doaj-a6df0cf06b0b42948586c5ba4a4640fe |
|---|---|
| record_format |
Article |
| spelling |
doaj-a6df0cf06b0b42948586c5ba4a4640fe2020-11-24T23:47:35ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2015-05-01310.3389/fcell.2015.00033137510A Top Down View of Tumor Microenvironment: Structure, Cells and SignallingRahul eBhome0Rahul eBhome1Marc eBullock2Marc eBullock3Hajir eAl Saihati4Rebecca eGoh5John ePrimrose6A. Emre eSayan7Alexander eMirnezami8Alexander eMirnezami9University of SouthamptonUniversity of SouthamptonUniversity of TexasUniversity of SouthamptonUniversity of SouthamptonUniversity of SouthamptonUniversity of SouthamptonUniversity of SouthamptonUniversity of SouthamptonUniversity of SouthamptonIt is well established that the tumour microenvironment contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular and immune. Signalling molecules secreted by the tumour corrupts these cells to create ‘activated’ stroma. Equally, the extracellular matrix contributes to tumour development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signalling components of the tumour microenvironment with a perspective on stromal soluble factors and microRNAs.http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00033/fullExtracellular MatrixMicroRNAsTumor MicroenvironmentCancer-associated fibroblastCancer stroma |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Rahul eBhome Rahul eBhome Marc eBullock Marc eBullock Hajir eAl Saihati Rebecca eGoh John ePrimrose A. Emre eSayan Alexander eMirnezami Alexander eMirnezami |
| spellingShingle |
Rahul eBhome Rahul eBhome Marc eBullock Marc eBullock Hajir eAl Saihati Rebecca eGoh John ePrimrose A. Emre eSayan Alexander eMirnezami Alexander eMirnezami A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling Frontiers in Cell and Developmental Biology Extracellular Matrix MicroRNAs Tumor Microenvironment Cancer-associated fibroblast Cancer stroma |
| author_facet |
Rahul eBhome Rahul eBhome Marc eBullock Marc eBullock Hajir eAl Saihati Rebecca eGoh John ePrimrose A. Emre eSayan Alexander eMirnezami Alexander eMirnezami |
| author_sort |
Rahul eBhome |
| title |
A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling |
| title_short |
A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling |
| title_full |
A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling |
| title_fullStr |
A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling |
| title_full_unstemmed |
A Top Down View of Tumor Microenvironment: Structure, Cells and Signalling |
| title_sort |
top down view of tumor microenvironment: structure, cells and signalling |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Cell and Developmental Biology |
| issn |
2296-634X |
| publishDate |
2015-05-01 |
| description |
It is well established that the tumour microenvironment contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular and immune. Signalling molecules secreted by the tumour corrupts these cells to create ‘activated’ stroma. Equally, the extracellular matrix contributes to tumour development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signalling components of the tumour microenvironment with a perspective on stromal soluble factors and microRNAs. |
| topic |
Extracellular Matrix MicroRNAs Tumor Microenvironment Cancer-associated fibroblast Cancer stroma |
| url |
http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00033/full |
| work_keys_str_mv |
AT rahulebhome atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT rahulebhome atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT marcebullock atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT marcebullock atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT hajirealsaihati atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT rebeccaegoh atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT johneprimrose atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT aemreesayan atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT alexanderemirnezami atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT alexanderemirnezami atopdownviewoftumormicroenvironmentstructurecellsandsignalling AT rahulebhome topdownviewoftumormicroenvironmentstructurecellsandsignalling AT rahulebhome topdownviewoftumormicroenvironmentstructurecellsandsignalling AT marcebullock topdownviewoftumormicroenvironmentstructurecellsandsignalling AT marcebullock topdownviewoftumormicroenvironmentstructurecellsandsignalling AT hajirealsaihati topdownviewoftumormicroenvironmentstructurecellsandsignalling AT rebeccaegoh topdownviewoftumormicroenvironmentstructurecellsandsignalling AT johneprimrose topdownviewoftumormicroenvironmentstructurecellsandsignalling AT aemreesayan topdownviewoftumormicroenvironmentstructurecellsandsignalling AT alexanderemirnezami topdownviewoftumormicroenvironmentstructurecellsandsignalling AT alexanderemirnezami topdownviewoftumormicroenvironmentstructurecellsandsignalling |
| _version_ |
1725489142531358720 |